HIF1a induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

Wenyu Zhou, Michael Choi, Daciana Margineantu, Lilyana Margaretha, Jennifer Hesson, Christopher Cavanaugh, C Anthony Blau, Marshall S Horwitz, David Hockenbery*, Carol Ware* and Hannele Ruohola-Baker* H Ruohola-Baker Department of Biology, University of Washington, Seattle, WA, USA, Institute for Stem Cell and Regenerative Medicine (ISCRM), Seattle, WA, USA, Department of Biochemistry, University of Washington, Seattle, WA, USA, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA, Department of Comparative Medicine, University of Washington, Seattle, WA, USA, Division of Hematology, University of Washington, Seattle, WA, USA and Department of Pathology, University of Washington, Seattle, WA, USA